Antioxidants inhibit low density lipoprotein oxidation less at lysosomal pH: a possible explanation as to why the clinical trials of antioxidants might have failed
145 The excess amount of superoxide damages tissues via oxidative stress by reducing the activation and proliferation of T lymphocytes
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The value of GSH and nutritional strategies like amino acids, vitamins, minerals, phytochemicals, sulforaphane to enhance cellular Nrf2, and other supplements used to restore GSH levels (327330) as adjunct treatments for all inflammatory diseases including SARS-CoV-2 infection needs to be further emphasized
Comparing the effects seen here to a model using a melatonin-competent mouse, for example from the CBA strain, would be beneficial for future studies that consider in more detail the phasing of melatonin treatment in vivo