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Nicotine is a vasoconstrictor - meaning that it constricts blood vessels throughout your body

There are 16 references cited in this article, which can be found at the bottom of the page

Parallel evidence from studies of e-cigarettes tells a similar story

The longer answer is that while a refill could last up to several days for a light vaper, a heavier vaper might finish one in a fraction of that time

[11] Spearheaded by the Sociedad Econmica de los Amigos del Pas (Economic Societies of Friends of the Country), tobacco was cultivated under strict government control confined to the Cagayan Valley, the Ilocos provinces, Nueva Ecija and Marinduque