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Retatrutide combines GLP-1, GIP, and glucagon agonism for triple-pathway engagement, while Liraglutide targets GLP-1 alone

From 2004 to 2009, an analysis of the database revealed a six-fold increase in pancreatitis incidents linked to the DPP-4 inhibitor sitagliptin and the GLP-1 mimetic exenatide, the first two GLP-1-based medications marketed in the US [51]

ADHD, substance use history, chronic stress, and medication side effects can also affect sleep quality

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