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5.4 Biomarker-guided treatment In the precision treatment strategy for gemcitabine resistance, biomarker guided treatment based on dynamic monitoring of RRM2 copy number based on ctDNA and multi-omics prediction models (such as the EXPLOR trial) provides a new paradigm for individualized intervention: Gemcitabine resistance, RRM2 gene copy number amplification drives resistance by accelerating deoxyribonucleotide triphosphate (dNTP) synthesis and enhancing DNA repair, while ctDNA-based liquid biopsy technology (such as ddPCR/NGS) can dynamically monitor the level of RRM2 amplification and track the evolution of resistant clones in real time

The adult rat hippocampus contains primordial neural stem cells

Melatonin, recognized for its dual role as an antioxidant and hormone, emerges as a promising candidate for mitigating AD pathology

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We schedule follow-up visits, review your progress and adjust your plan to help you get the best possible results.