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People with active cancer or history of cancer within 5 years should avoid use because growth factors and angiogenesis promotion could theoretically affect tumor growth

Calibration and use of the polar organic chemical integrative samplera critical review

10.3389/fphys.2016.00064 31 FoxE

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Animal models frequently employ single high doses or repeated supraphysiological doses (e.g., 100200 mg/kg, i.p.) to induce rapid ovarian failure, while human chemotherapy protocols typically involve lower fractionated doses administered over longer periods