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10.1038/s41467-017-02085-z

This review consolidates existing knowledge, identifies gaps, and suggests directions for future research to better understand the potential of melatonin for neuroprotection and disease mitigation within the landscape of AD

Aside from assessing the effectiveness and safety of HMB treatments, future clinical trials can incorporate self-reported outcomes such as quality of life and participant satisfaction, include a cost-effectiveness component, and be conducted for a more extended treatment period

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