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Phase I metabolism generates primary metabolites, which are often intermediate products with increased polarity compared to the parent compound

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It is also thought to transport nutrients to lymphocytes and phagocytes, which are the body's main defense cells

Table 2 reviews the clinical studies of the mentioned vitamins

The findings closed the loop, linking a metabolite and its transporter to metastasis by demonstrating that mitochondrial glutathione import via the SLC25A39 transporter is essential for cancer spread