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In fact the interspecies variability in N -glucuronidation is particularly high, especially for aliphatic tertiary amines and, relevant to the LEO drug compound, aromatic N -heterocycles

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Combined, these studies involved fewer than 30 human subjects and lacked control groups none used a randomized, placebo-controlled design

PMC Mayo Clinic Proceedings: Cardiovascular and Other Health Benefits of Sauna Bathing

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