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The risk, however, lies less with the molecule itself than with the quality of the preparation and the conditions of administration: a cluster of seven cases of endotoxin poisoning was described after infusions prepared from contaminated raw material not intended for intravenous use (Johnstone et al., Epidemiology and Infection 2018, PMID 29673413)
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The fact that following infection, cancer develops without pretreatment with nitro-carcinogens such as N-methyl-N-nitrosourea, indicates that the chronic inflammatory process initiated by this infection is the driving force for neoplasia (70)
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CymaBay Therapeutics reports topline 12-week data from an ongoing phase 2b study of seladelpar in patients with nonalcoholic steatohepatitis
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