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revealed that adding atorvastatin (20 mg/day, P.O for 4 weeks) reduced plasma MDA while improving the functional capacity assessed via a 6-minute walk test in patients with chronic heart failure (CHD) [228]

Notably, BUD13 immunoprecipitated WT F-SNIP1 more efficiently than the F-SNIP1 mutants, indicating a reduced ability of the mutants to associate with the activated spliceosome (Fig