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This disease is characterized by increased lipid peroxidation and protein carbonyl (PC) concentrations, as well as a decrease in antioxidant enzyme activity such as GPx, SOD, and CAT (63)

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HO-1 is a key mediator of ferroptosis and plays an important role in the development of various diseases ( 6 Conclusion and Perspective Delayed wound healing of diabetic ulcers involves multiple pathological mechanisms, including peripheral nerve and blood vessel injury and increased inflammation cascades

Therefore, basic research to clinical transformation remains the rate-limiting step in the development of treatment strategies for ASD, and the degree of heterogeneity may be considered, which may obscure the effect of experimental treatments