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None of these routes are approved for clinical or therapeutic use in humans, and all remain experimental

However, it appears that while it has been extensively studied in experimental and animal models, there is no clear evidence that it has been widely approved for clinical use of standard treatments in humans by the FDA

Clinical trials would need an IND protocol

Bethesda: American Physiological Society: 774780

So, if you ask yourself, "why B12 shots are better than oral supplements?" - you know that injections have a much higher and quicker response time than ingestion