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Eligible participants were males and females between the age of 18 and 80 years and had a clinical diagnosis of fibromyalgia (according to the 2010 American College of Rheumatology criteria ( th and 50 th percentile for age-appropriate levels of IGF-1) ( After informed consent was obtained, demographics and baseline medical history were collected, and a baseline psychological examination was performed

Furthermore, copper can stimulate the activity of an enzyme called cystathionine beta-synthase (CBS), which converts homocysteine to cystathionine in the methionine cycle