Gliotoxin was administrated to female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein with a dose of 1 mg/kg, which can aggravate the symptom of neuroinflammation via the upregulation of inflammatory genes, including T-box transcription factor (TBX21), inducible nitric oxide synthase (iNOS), arginase 1 (ARG1), and cytokines such as IFN-, IL-17, and IL-2 [48]
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Moreover, PS externalization, which is one culmination point of eryptosis signaling, is known to be immunosuppressive and antiinflammatory [233]
This is crucial for maintaining overall health and reducing the risk of chronic diseases