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During the process of drug and alcohol detoxification, our body goes through immense stress due to the elimination of harmful substances and the physiological adjustments necessary for recovery
[DOI] [PMC free article] [PubMed] [Google Scholar] 243
Furthermore, most preclinical studies have used short-term high-glucose or db/db mouse models, which fail to recapitulate the chronic, progressive nature of human DN (e.g., long-term fibrosis and comorbidity-associated complications)