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The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

It also supports collagen production, improves fibroblast activity (important for wound healing), and helps regulate inflammatory cytokines

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This mechanical effect complements the central nervous system effects, providing multiple reinforcing signals that reduce total food intake without requiring conscious effort