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The most common causes include: Inadequate dietary intake (common in vegetarians/vegans) Malabsorption syndromes (e.g., celiac or Crohns disease) Atrophic gastritis Long-term use of acid-reducing medications Pernicious anemia (an autoimmune condition) B12 deficiency is one of the leading reversible causes of anemia

The clinical use track record in Eastern Europe and Asia provides a level of real-world safety and efficacy data that purely preclinical peptides lack, though large-scale randomized controlled trials specifically for peripheral neuropathy are still needed

Skipping doses or irregular administration can diminish the benefits and may require a period of readjustment to get back on track

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Arafa M, Agarwal A, Majzoub A, et al