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Base of the iceberg The base of the metabolic iceberg is represented by environmental and genetic factors that damage mitochondria or force maladaptive adjustments in their biology

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We then used mass cytometry (CyTOF), which allows for measurement of key metabolic transporters and enzymes as well as phenotypic and functional proteins 4 , to study the immunometabolic profile at the single-cell proteomic level (Fig

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