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Mechanical forces can lead to changes in DNA methylation, histone modifications, and non-coding RNA expression, which in turn affect gene expression and cellular behavior

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[52] [53] Subsequent meta-analyses of the effects of low versus high dietary folate, elevated serum folate, and folic acid supplementation have reported conflicting results

It should be emphasized that during corticosteroid therapy prolonged for more than 2 weeks, there is a risk of developing adrenocortical insufficiency, which is manifested by the inhibition of ACTH secretion and adrenal atrophy