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For instance, sour tea (2040 mg/kg) taken with hydrochlorothiazides (10 mg/kg) significantly increased urine volume in rats, raising the risk of dehydration (667)

The problem is the science hasnt caught up. Peptides have been studied for decades, and some have gained FDA approval for use in medications, including insulin and GLP-1s

[1] Mike points out a potential issue with comparing pure L-citrulline to citrulline malate , since the latter contains less actual citrulline by weight

15 kDa selenoprotein The 15 kDa selenoprotein SELENOF (formerly selenoprotein 15