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10.1194/jlr.R048975 37

Hydroxycarbamide is beneficial in treating sickle cell disease through its ability to stimulate fetal hemoglobin synthesis

(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

Characteristics of the peptides are summarized in table 2

however, ABHD5 lacks an active serine found in other ABHD family members (33), in which possibilities might include promoting access to the TAG core through remodeling of the phospholipid monolayer, or removal of reaction products