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Combination with professional treatments (fillers, energy-based devices) often produces better nasolabial fold results than either approach alone

[DOI] [PubMed] [Google Scholar] 10.Cotgreave I.A

However, these cell types often exhibit divergent requirements for media composition, mechanical stimuli, oxygen tension, and ECM cues, making it difficult to maintain their viability and phenotypic stability within a single device (203)

They take the form of red, purple, or silver lines, frequently becoming visible on areas such as the abdomen, thighs, and hips