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Once these two parts are prepared, structure-based drug design can be carried out, which is currently the most common screening method and is often divided into receptor-based direct methods and ligand-based indirect methods

451,452,453 These medications demonstrate significant clinical efficacy within their respective therapeutic areas, and in some cases, promote the generation of H 2 S, providing a novel pharmacological mechanism for the protection of the cardiovascular system and other organs

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doi: 10.1016/0098-2997(94)90035-3