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DNA Repair: NAD+ is a substrate for enzymes known as PARPs (poly-ADP-ribose polymerases), which are involved in repairing DNA damage

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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

Diabetologia 52(11):23502358