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Metabolic disruption also extends to thrombotic mechanisms: platelet activation requires a glycolytic ATP surge mediated by HK2 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), while hyperglycemia stiffens clots via advanced glycation end-product (AGE) crosslinking

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Eur J Biochem 98:487499 Loprasert S, Whangsuk W, Sallabhan R, Mongkolsuk S (2005) The unique glutathione reductase from Xanthomonas campestris : gene expression and enzyme characterization

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