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ROS promotes an increase in glycolysis in cellular respiration, shifting away from OXPHOS, which may contribute to tumorigenesis by triggering the Warburg effect [42]

These findings together suggest that PKM2 elimination can not only deal with the inflammatory injury of chondrocytes but also inhibit ER stress-mediated apoptosis by antagonizing the Rspo2/Wnt/-catenin pathway (38)

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Cartilage Repair Potential Emerging research suggests AOD-9604 may also support cartilage regeneration, adding a secondary benefit for patients dealing with joint health concerns alongside their body composition goals