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In a study including N=58 patients affected by endometriosis and surgically diagnosed with the condition, the use of pycnogenol at 60mg/day for 48 weeks significantly reduced the symptoms score (N=26) as well as CA-125 levels (a serum marker of endometriosis) although in patients treated with hormones therapy (N=26), the benefits are even more pronounced

At 48 h post-injection, the mice were euthanized to collect tumors and major organs for subsequent ex vivo imaging

The promising ex vivo skin distribution profile, as exhibited by increased dermal deposition, indicates the ability of the nano-formulation to form a localized dermal drug depot

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