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Computational drug discovery in ankylosing spondylitis-induced osteoporosis based on data mining and bioinformatics analysis

Tesamorelin activates the GHRH receptor (a class B G-protein-coupled receptor), triggering a cAMP-PKA signaling cascade that upregulates growth hormone gene transcription and increases somatotroph sensitivity to subsequent secretagogue signals

Additionally, tolizumab has demonstrated therapeutic efficacy in managing systemic juvenile idiopathic arthritis, adult Stills disease, and Crohns disease (251)

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