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However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

J Immunol (2010) 184:4119

Depolarization and reduced glutamate reuptake activity due to hypoxia leads to elevated extracellular glutamate levels

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The skin tensile strength provided by fibrillar collagens is complemented by the elastic fibre network which endows skin with resilience, allowing it to return to a resting state following deformation