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A Philip Morris exec once wrote, hitting the youth can be more efficient even though the cost to reach them is higher, because they are willing to experiment, they have more influence over others in their age group than they will later in life, and they are far more loyal to their starting brand. Quote taken from Tobacco Explained.

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Thus, we used the methylated genes from blood samples more extensively for pathway-based analysis and used the methylated genes from buccal samples only for replication

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To further investigate the influence of smoking reduction, we modelled the amount of change in smoking as a continuous variable using restricted cubic splines