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Originating from the abnormal physiological state that causes epilepsy, breakage of the BBB loop leads to changes in permeability that can ultimately lead to abnormal entry of substances from small molecules to intact cells (17, 65), which is in turn evidence of microvascular dysfunction in epilepsy (66, 67)

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87.5% fibroblast viability

Patients may need 100500 mg/day IV thiamine to prevent or sometime leads Wernickes encephalopathy a life-threatening complication causing confusion, memory loss, and poor coordination