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This trend is particularly evident in both high-income and middle-income countries, where tobacco consumption is often higher in these populations due to factors such as affordability of tobacco products, limited access to cessation resources, and social norms that may condone smoking 32

For the U.S., the Mullers cited 2013 estimates that compared average air pollution to smoking 0.41 cigarettes daily

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Diacetyl-induced bronchiolitis obliterans first occurred in workers at a microwave popcorn production facility, which resulted in the disease being described as popcorn lung. A recent study investigating whether this known inhalational toxicant was present in sweet-flavored e-liquids revealed diacetyl in 110 (69.2%) of the 159 products tested [73]