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Mar 2020;37(3):414-424

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NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

In 39 patients (19 in the loading dose group and 20 in the no loading dose group), MMSE scores were similar at baseline (27 vs