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Jul 2012;97(7):1008-1013

median observation time of 49 months for the second) were able to provide valuable information on its natural history, estimate the sample size needed for statistically powerful clinical trials, and conclude on the patients/diseases characteristics that correlate more with disease progression [243, 244]

The mechanism is still unclear, but one oft-cited study of women who were overweight or obese and also had prediabetes found that NAD supplementation with nicotinamide mononucleotide (NM), an NAD precursor, for 10 weeks improved insulin sensitivity

However, these associations likely reflect underlying disease processes rather than B12 toxicity itselfelevated B12 is often a marker of serious illness rather than its cause

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