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Lipoic acid has also been shown to improve nitric oxide (NO)-dependent vasodilation in aged rats by increasing PKB/Akt-dependent phosphorylation of endothelial NO synthase (eNOS) and eNOS-catalyzed NO production (47)

Ca can originate from intracellular organelles or enter from the extracellular environment through specific ion channels, including Ca release-activated Ca channels, transient receptor potential (TRP) channels and L-type voltage-gated Ca channels

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The instrument was set to gradually increase the temperature (2 C/min) from 25 C to 95 C

We have previously shown that, through catalyst-directed CH functionalization, the most accessible primary, secondary and tertiary CH bonds within a linear alkane substrate could be selectively functionalized by using catalyst 2 , 3 or 4