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Obayan, A

The methylenetetrahydrofolate reductase enzyme(MTHFR), which is encoded by the MTHFR gene, is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation

Thornberry N, Lazebnik Y (1998)

When patients encounter the same allergen again, mast cells and basophils will undergo IgE-mediated activation, which promotes the release of inflammatory mediators, especially histamine and leukotrienes

Beyond folate and methylation support therapy, addressing gut health, dysbiosis, and leaky gut is critical in reducing autoimmune activity and optimizing folate metabolism