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For example, Twist1-K150la simultaneously promotes its phosphorylation and nuclear translocation, consequently inducing the transcriptional activation of TGF1 in ECs

8 In idiopathic pulmonary fibrosis, for example, GSH concentrations are only 25% of normal values in the epithelial lining fluid and may be involved in the underlying pathophysiology of the disease

However, translating these mechanistic insights into clinical benefit is hindered by three interconnected challenges, each of which offers critical directions for future investigation