Graphical abstract Suspected clinical impacts of GLP-1RAs, SGLT2is, and finerenone oncardiovascular and kidney outcomes
Cracking the PROTAC Permeability Barrier: CD36-Mediated Endocytosis as a Potential Breakthrough 2025-12-03 In recent years, proteolysis-targeting chimeras (PROTACs) have shown tremendous promise in targeting "undruggable" proteins
Only certain cells in our bodies are capable of making histamine: Immune system: mast cells and basophils Digestive system: gastric enterochromaffin cells and certain gut bacteria Nervous system: histaminergic neurons (in the brain and body) Histamine can bind to four different kinds of receptors, and each receptor responds in its own special way to histamine
Collectively, these studies reinforce the versatility of CQDs, however comprehensive in vivo assessments of BBB transport, biodistribution, and long-term neurotoxicity are still required to substantiate clinical translational potential
Specialized nutrients like probiotics and omega-3 fatty acids degrade faster, making their post-expiry use particularly unreliable
