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Another potential mechanism suggested by experimental research is the potential GHK-Cu action on synthesis of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases (TIMPs), which are deemed crucial for extracellular matrix remodeling

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These occupy a regulatory gray zonethey are not making drug claims, but the inclusion of a recombinant growth factor in a topical product raises questions about proper classification under FDA cosmetic regulations (21 CFR Part 700 vs