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doi: 10.1093/ije/18.1.45 80 JonklaasJDanielsenMWangH

In a related rat model, activation of p62/Nrf2 and downregulation of ROS were also observed, as evidenced by reductions in arthritis scores and pathological features (marked infiltration of inflammatory cells, synovial hyperplasia, cartilage damage and bone destruction), as well as inhibition of NFATc1 and other osteoclast activities and bone resorption regulators (CTSK and MMP-9)

The long-term adherence to this combined intervention is crucial for sustained improvements in mood, cognitive function, and overall brain health

Nature 543, 15

Still, trained neurologists can usually detect irregularities in Cerebrospinal fluid biomarkers through radiography tools such as brain MRI or CT Scan