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Thus, activation of Nrf2 appears to be an attractive approach for treating or mitigating PD 9

However, when produced in excess, ROS can overwhelm cellular antioxidant defenses, leading to oxidative stress and the disruption of essential biomolecules, including nucleic acids, proteins, and membrane lipids

Eye (London) 30 , 169172 (2016)

Extensive discussion of the microbiome in the context of cancer is also omitted here, as it is a very large topic in its own right 4,5