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For patients with confirmed pernicious anaemia or malabsorption disorders, injectable therapy remains the recommended first-line treatment according to NICE CKS guidance, as oral supplementationregardless of dosecannot reliably correct deficiency in these circumstances

Because gluten proteins are rich in proline and glutamine, they resist complete proteolytic digestion and generate immunogenic peptides that can persist in the intestinal lumen

GSSG is then recycled back to GSH by glutathione reductase using NADPH

Lipinska et al., 2025), EVs have been applied using heterogeneous experimental protocols, with doses generally ranging from low g/mL concentrations (310 g/mL) to higher fixed doses around 120200 g/mL, and exposure times spanning from short co-culture periods of a few hours (up to 14 h) to prolonged treatments covering complete in vitro maturation windows according to the specie (approximately 1838 h)

ASIA AF 52, 40634074