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Lee et al., 2004

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Recent injuries that have not progressed to chronic degeneration typically respond faster than problems that have persisted for years

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The most common cause of chronic low-back pain is the deterioration of discs between the vertebrae

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However, this introduces unpredictability: the same dose could produce significantly higher plasma levels than intended, and the effect varies by inhibitor potency

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Phase 3 TRIUMPH-4 (NCT05931367) reported 28.7% body weight loss at 12 mg, 26.4% at 9 mg, vs 2.1% placebo at 68 weeks

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