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High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor

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FXR-deficient mice are resistant to obesity induced by a high-fat diet, and transferring their microbiota to germ-free wild-type mice reduces obesity and improves glucose tolerance, indicating that the gut microbiota promotes weight gain and hepatic steatosis in an FXR-dependent manner (Parsus et al., 2017)

This choice depends on the patients health and the doctors advice