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Safety Considerations in Canine Subjects Available research suggests: Toxicity data: Limited long-term toxicology studies in dogs specifically Side effects: Research in rodents generally reports minimal adverse effects at studied doses Drug interactions: Potential interactions with other medications not well characterized Monitoring: No established protocols for monitoring dogs receiving BPC-157 The absence of comprehensive safety data in dogs represents a significant knowledge gap

Data extraction and synthesis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological transparency and rigor