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From Week 9 onward, most users dose both on the same day at different injection sites

However, only ~ 50% patients with opioid-induced constipation exhibit satisfactory response to PAMORA-based clinical management strategies targeting MORs in the enteric nervous system, and we observed that naloxegol could only partially alleviate morphine-induced constipation

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Over time, the elastic fibers become damaged and the collagen network remodels to fit the larger shape