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It is a quinolinium salt substituted at position 5 with an amino group and at position 1 with a methyl group

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It has been suggested that death signals flows from RIP1 to RIP3 through their RHIM domains, resulting in recruitment of additional RIP3 molecules for signal propagation, implying that RIP3 oligomerization is the minimal functional unit that is required to drive necrosome assembly [121]

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