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SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, kidney disease, liver disease, neurodegeneration, and cancer

Neuroscience and Behavioral Physiology, 38(9), 953957

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The simultaneous reduction in pro-inflammatory cytokines and increase in anti-inflammatory IL-10 also addresses the neuroinflammatory component that many researchers now believe drives Alzheimer progression as much as amyloid itself