Serum samples were assayed for general clinical chemistry markers [i.e., glucose, total protein, blood urea nitrogen (BUN), creatinine, BUN/creatinine ratio, uric acid, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), albumin, globulin, sodium, chloride, calcium, carbon dioxide, total bilirubin, alkaline phosphatase, triglycerides, cholesterol, high density lipoprotein (HDL), and lower density lipoprotein (LDL)]
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Moreover, ammonium contributes to metabolic acidosis in the TME by forming ammonium ions (NH 4 + ), lowering the pH, disrupting redox balance, and further suppressing NK cell function
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It is especially common among older adults, individuals with specific health conditions, children, or those following predominantly or exclusively plant-based diets
