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However, it proved ineffective and was discontinued for this use

It can be concluded that citrate buffer 0.1M (pH=3.1) has less stabilizing effect compared to phosphate buffer (0.05 M, pH= 5.8)

In some embodiments, the otoprotectant is a compound of Formula (V) having the structure of Formula (Va): In some embodiments, the otoprotectant is a compound of Formula (VI): wherein: X is a pharmaceutically acceptable counterion

Moreover, another study has reported the change in the composition of gut microbiota in growth hormone-secreting pituitary adenoma and nonfunctional pituitary adenoma characterised by a significant increase in -diversity compared to controls [185]

The supplement investigated in this paper was supplied at no cost by the manufacturing company, Lo.Li